| Coaches | |
|---|---|
| Position | Name |
| Head Coach | Kyle Shanahan |
| Offensive Coordinator | Klay Kubiak |
| Defensive Coordinator | Robert Saleh |
| Special Teams Coach | Brant Boyer |
| Offense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| QB | 13 | Brock Purdy | 10 | Mac Jones | ||||||
| RB | 23 | Christian McCaffrey | 8 | Brian Robinson | 31 | Isaac Guerendo | 29 | Jordan James(R) | ||
| LWR | 17 | Jordan Watkins(R) | 24 | Skyy Moore | ||||||
| SWR | 15 | Jauan Jennings | 19 | Jacob Cowing | ||||||
| RWR | 1 | Ricky Pearsall | ||||||||
| TE | 85 | George Kittle | 89 | Luke Farrell | 88 | Jake Tonges | ||||
| FB | 44 | Kyle Juszczyk | ||||||||
| LT | 71 | Trent Williams | 74 | Spencer Burford | ||||||
| LG | 78 | Ben Bartch | 55 | Drew Moss(R) | ||||||
| C | 64 | Jake Brendel | 61 | Matt Hennessy | ||||||
| RG | 77 | Dominick Puni | 75 | Connor Colby(R) | ||||||
| RT | 68 | Colton McKivitz | 62 | Austen Pleasants | ||||||
| Defense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| LDE | 97 | Nick Bosa | 94 | Yetur Gross-Matos | 51 | Robert Beal Jr. | ||||
| RDE | 98 | Mykel Williams(R) | 47 | Bryce Huff | 91 | Sam Okuayinonu | ||||
| LDT | 92 | Jordan Elliott | 99 | CJ West(R) | ||||||
| RDT | 93 | Kalia Davis | 95 | Alfred Collins(R) | 58 | Evan Anderson | ||||
| WLB | 53 | Dee Winters | 45 | Nick Martin(R) | ||||||
| MLB | 54 | Fred Warner | 57 | Luke Gifford | 48 | Tatum Bethune | ||||
| LCB | NA | Renardo Green | 28 | Darrell Luter Jr. | ||||||
| RCB | 2 | Deommodore Lenoir | 33 | Siran Neal | ||||||
| SS | 25 | Jason Pinnock | 24 | Richie Grant | ||||||
| FS | 36 | Marques Sigle(R) | 27 | Ji'Ayir Brown | ||||||
| NB | 20 | Upton Stout(R) | 26 | Chase Lucas | ||||||
| Special Teams | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | ||||
| K | 4 | Jake Moody | ||||||||
| LS | 46 | Jon Weeks | ||||||||
| PR | 19 | Jacob Cowing | 24 | Skyy Moore | 17 | Jordan Watkins(R) | 1 | Ricky Pearsall | ||
| KR | 31 | Isaac Guerendo | 24 | Skyy Moore | ||||||
| KO | 4 | Jake Moody | ||||||||
