| Coaches | |
|---|---|
| Position | Name |
| Head Coach | Kyle Shanahan |
| Offensive Coordinator | |
| Defensive Coordinator | Nick Sorensen |
| Special Teams Coach | Brian Schneider |
| Offense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| FB | 44 | Kyle Juszczyk | ||||||||
| QB | 13 | Brock Purdy | 5 | Joshua Dobbs | 17 | Brandon Allen | ||||
| RB | 23 | Christian McCaffrey | 25 | Elijah Mitchell | 49 | Isaac Guerendo | 24 | Jordan Mason | 32 | Patrick Taylor |
| TE | 85 | George Kittle | 81 | Cameron Latu | 82 | Eric Saubert | 9 | Brayden Willis | 88 | Jake Tonges |
| WR | 1 | Deebo Samuel Sr. | 11 | Brandon Aiyuk | 15 | Jauan Jennings | 14 | Ricky Pearsall | 83 | Jacob Cowing |
| Defense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| FS | 27 | Ji'Ayir Brown | 30 | George Odum | 41 | Tayler Hawkins | ||||
| LCB | 7 | Charvarius Ward | 31 | Renardo Green | 22 | Isaac Yiadom | NA | Samuel Womack III | 38 | Kemon Hall |
| LDE | 56 | Leonard Floyd | 95 | Drake Jackson | 58 | Alex Barrett | 67 | Sam Okuayinonu | 60 | Raymond Johnson III |
| LDT | 99 | Maliek Collins | 90 | Kevin Givens | 93 | Kalia Davis | NA | Earnest Brown IV | ||
| MLB | 54 | Fred Warner | 45 | Demetrius Flannigan-Fowles | 50 | Jalen Graham | ||||
| RCB | 2 | Deommodore Lenoir | 20 | Ambry Thomas | 33 | Rock Ya-Sin | 26 | Chase Lucas | ||
| RDE | 97 | Nick Bosa | 94 | Yetur Gross-Matos | 51 | Robert Beal Jr. | 40 | Austin Bryant | ||
| RDT | 98 | Javon Hargrave | 91 | Jordan Elliott | 96 | T.Y. McGill | 67 | Isaac Alarcon | ||
| SLB | 59 | De'Vondre Campbell | 47 | Ezekiel Turner | 48 | Tatum Bethune | ||||
| SS | 29 | Talanoa Hufanga | 43 | Malik Mustapha | 35 | Erik Harris | ||||
| WLB | 57 | Dre Greenlaw | 36 | Curtis Robinson | 53 | Dee Winters | ||||
| Special Teams | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | ||||
| K | 4 | Jake Moody | ||||||||
| KR | 10 | Ronnie Bell | 19 | Trent Taylor | 14 | Ricky Pearsall | ||||
| P | 3 | Mitch Wishnowsky | ||||||||
| PR | 10 | Ronnie Bell | 14 | Ricky Pearsall | 19 | Trent Taylor | ||||
